I worked in Monahans,TX long ago as a computer programmer and used to run a few miles every night even during those harshly cold West Texas winters. As a young man, I felt physically and medically invincible until one day when I felt sharp pains in my chest whenever I coughed or even took a deep breath.
I had Pleurisy which is an inflammation of the lining of the lungs and chest (the pleura). I believe the doctor gave me a sulfa antibiotic script to arrest the infection and I became much more circumspect about running in the dry cold in the sand hills city.
I was a little worried to learn that malignant mesothelioma can also originate in the pleura lining and has causes other than asbestos exposure.
I have not had Pleurisy since nor have I heard of any of my friends, relatives or colleagues being afflicted with it. I remember a college biology professor saying your lungs may as well be an external organ given their exposure to non filtered air. I guess that is why second hand cigarette smoke is so potentially harmful to your health.